Modified risk tobacco products (MRTP) offer a promising alternative in the harm reduction strategy for adult smokers unable to quit. One of my first moves when I took over as Acting, Director of FRAME in January 1982, just after the, move from Wimbledon to Nottingham, was to pur-. The use of PL allowed for activation of crucial signaling proteins associated with DC differentiation and maturation. Access to society journal content varies across our titles. Generated DCs were assessed for their morphology, viability, endocytotic capacity, surface phenotype (immature, mature and tolerogenic DCs) and activation of important signaling pathways. 1983 - FRAME joined with the British Veterinary Association (BVA) and the Committee for the Reform of Animal Experimentation (CRAE) to advise the government on the … That does not surprise me, since I have long been aware that individuals and, institutions, faced with an ever increasing num-, ber of journals with ever increasing costs, must, make difficult choices. Login failed. Anyone who wants to read the articles should pay by individual or institution to access the articles. editorial in the morning, and have it reviewed, edited, typeset and ready for publication before, the end of the day. Unfortunately, this widening of the scope of the, journal did not lead to a sufficient increase in cir-, culation, so, in 1980, the FRAME Trustees decided, transformed, in two stages, into a more conven-, ATLA (Alternatives to Laboratory Animals), Looking back from the perceived sophistication. We can receive a manuscript from an author and, fully process it within a week, and I can write an. of today’s instant-information-dominated world, © 2008-2021 ResearchGate GmbH. on pages per volume and no budget restrictions. As the focus on news & views, comments and, review articles, original research papers, and. Show simple item record. Alternatives to laboratory animals: ATLA, 41(6), 453-459. ATLA is intended to cover all aspects of the development, validation, introduction and use of alternative methods. In the present study, we investigated and compared the impact of the aerosol from the candidate MRTP, THS2.2, with that of CS, on human gingival epithelial organotypic cultures. The study used Grounded Theory to analyze the interviews and developed a model that consists of 4 major themes: (a) "attitudes toward animals," (b) "knowledge of animal use procedures," (c). London, UK: FRAME. Join ResearchGate to find the people and research you need to help your work. ATLA is an international, peer-reviewed scientific journal, publishing articles on the latest research relating to the development, validation, introduction and use of alternatives to laboratory animals. Cells were isolated from buffy coats from healthy volunteers using immunomagnetic selection. ATLA. An alternative to laboratory animal experimentation for human health risk assessment. More changes were to follow very rapidly, since, by June 1982, it was announced that, from volume, year, rather than only twice, with an international. ATLA is a peer-reviewed journal, intended to cover all aspects of the development, validation, implementation and use of alternatives to laboratory animals in biomedical research and … This study indicates that exposure to THS2.2 aerosol had a lower impact on the pathophysiology of human gingival organotypic cultures than CS. ATLA. This site uses cookies. (1983). Burkett, M. of today’s instant-information-dominated world, this might all seem rather naïve. T2 - The report and recommendations of ECVAM workshop 18. Animals and Alternatives in Toxicity Testing, 550pp. Alternatives To Laboratory Animals (ATLA) is published 6 times per annum by FRAME. New products are emerging with numerous variations in designs and performance parameters within and across brands. Burkett, M. reviewers, secretaries, sponsors, and, especially, authors, whose contributions have been so vital, to the journal’s survival, let alone its success. Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including periodontal diseases, gingivitis and other benign mucosal disorders. as they become available. Background aims: Times are changing, and the Three Rs are increasing being politicised: and FRAME is particularly well placed to ensure that good science and good welfare, rather than ideology, remain the basis for interest in and progress with the Three Rs. ATLA reports on the latest news and events, reviews publications and products, and lists the most significant recent research papers. The, larger page was also more suitable for the com-, and, in particular, reports on prevalidation and, validation studies. It is an international, peer-reviewed scientific journal, publishing articles on the latest research relating to the Smoking is one of the major lifestyle-related risk factors for periodontal diseases. ATLA. Using a systems toxicology approach, we investigated and compared the exposure effects of a reference cigarette (3R4F) and a heat-not-burn technology-based candidate MRTP, the Tobacco Heating System (THS) 2.2. AU - Lambré, Claude R. AU - Aufderheide, Michaela DCs were differentiated in RPMI1640 supplemented with either 10% fetal bovine serum (FBS), 10% AB serum or 10% PL with the addition of granulocyte monocyte colony stimulating factor and interleukin-4. FRAME'S contributions to progress based on the Three Rs (replacement, refinement, reduction) concept of alternatives are reviewed, with particular emphasis on FRAME'S journal ATLA (Alternatives to Laboratory Animals) , the work of the FRAME Toxicity Committee, the FRAME Research Programme, the British Animals (Scientific Procedures) Act 1986 and Directive 86/609/EEC, the use of … Research assessing the potential effects of ENDS exposure in humans is currently limited and inconclusive. However, the work was, very labour-intensive, since in 1973 there were no, fax machines, no word processors, no office com-, puters or personal computers, no helpful com-, puter programs such as Word Perfect or Word, no, e-mails, no World Wide Web, and no Internet. The Standard Abbreviation (ISO4) of ATLA Alternatives to Laboratory Animals is Altern Lab Anim. In addition, recommendations based on the 3Rs (Refinement, Reduction, Replacement) principle also recommend the use of non-animal sera in in vitro studies. NAL. book reviews increased, all contacts were by mail: manuscripts were received, referees’ comments, requested and received, revised manuscripts, requested and received, and proofs sent and, returned — all by post, which took weeks, if not, included were selected from literature surveys reg-, ularly conducted for FRAME by Pfizer Central, Research, Sandwich, Kent, UK, through the good, offices of Dr David Bawden, Dr Ian Sinclair, and, Hunter’s insistence, and was made possible by her. ©2009—2021 Bioethics Research Library Box 571212 Washington DC 20057-1212 202.687.3885 A systems toxicology approach was employed combining cellular assays (i.e. Reviews, 1976-1979, 104pp. Meanwhile, we had obtained, our first word processor, a Commodore, which may, and December 1982), and was certainly used to, of a conference held at the Royal Society in 1982, to, discuss the first report of the FRAME Toxicity, 438 Editorial. A framework for in vitro systems toxicology assessment of e-liquids, Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells, Systems toxicology assessment of repeated exposure to cigarette smoke and a potential modified-risk tobacco product aerosol on gingival organotypic cultures, Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study, Human platelet lysate is a successful alternative serum supplement for propagation of monocyte-derived dendritic cells, 3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product_suppl, ATLA Evolves to the Next Stage: FRAME is partnering with SAGE Publishing to take ATLA forward, Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures, The safety of innovative tobacco-related products and of e-cigarettes, "I'm Not Going to Make a Song and Dance about It ... ", Response to Protocol Review Scenario: Approval is appropriate, Response to Protocol Review Scenario: An interesting dialog, Breeding without research.
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