Science and health explained and analysed with a rigorous focus on the evidence. March 9, 2021 -- The Pfizer/ and Moderna vaccines donât work as well against the coronavirus variant first discovered in South Africa as they do against the dominant ⦠But I think if I recall correctly, it was like six or eight in the placebo group and none in the vaccinated group. The South African and UK variants share the N501Y mutation, but the South African strain also includes mutations known as E484K and K417N. It's also important to remember that several of these top companies have efforts under way targeting these variants specifically. We've known that for at least a couple of months probably, that none of the currently available vaccines are quite as effective, we don't know exactly how effective they are going to be against the South African variant. I think that's old news. Pfizer and BioNTech said Thursday their Covid-19 vaccine was highly effective against the South African variant in the latest phase of ⦠April 13, 2021 -- An Israeli study found that the South African coronavirus variant, B.1.351, can âbreak throughâ protection offered by the Pfizer/BioNTech vaccine, Reuters has ⦠Stock Advisor launched in February of 2002. In two separate British studies, researchers looked at thousands of households where a person fell sick. “It’s reassuring,” said Professor Fiona Russell, an adviser to the World Health Organisation on vaccines, based at the Murdoch Children’s Research Institute. One of the largest mysteries that remains about vaccines is how well they stop infected people passing on the virus. Stock Advisor list price is $199 per year. They looked at people who were infected with the coronavirus over the same time period and then they broke them into two different groups, the group that had been previously vaccinated and the group that hadn't been previously vaccinated, and then they asked what strains of the virus had caused the infection. In clinical trials, Pfizer’s mRNA vaccine recorded an efficacy against symptomatic infection of about 95 per cent, while AstraZeneca’s was closer to 70 per cent, leading to concerns the AstraZeneca jab was inferior (despite both offering seemingly complete protection against severe illness and death). Concern about that variant reached fever pitch when researchers published a study in March suggesting AstraZeneca’s vaccine offered no protection against catching it. The variant of COVID-19 first seen in South Africa, known as B.1.351, has a collection of mutations that appear to cut the ability of antibodies to stop it binding to and entering human cells. Sign up to The Age’s here and the Sydney Morning Herald’s here. Discounted offers are only available to new members. The large study took swabs from a random selection of people every week; it collected more than 1.6 million swabs between December and April. It's hard in a study like this to back that out and put it as an efficacy number because obviously, there's a heck of a lot less people who were vaccinated that got infected than there were unvaccinated people who got infected if you look at the two populations. It found that two doses of Pfizer or AstraZeneca cut the risk of catching COVID-19 by 70 per cent. A new study shows the new Pfizer-BioNTech COVID-19 vaccine is effective against the South African variant of the virus, although it generates a slightly lower immune response. In April, the companies announced that a small trial in South Africa had found the vaccine to be fully effective against B.1.351, but the study of ⦠Keith began writing for the Fool in 2012 and focuses primarily on healthcare investing topics. Australia’s coronavirus vaccine strategy has received a boost with evidence showing Pfizer’s vaccine offers good protection against COVID-19’s new variants. Cumulative Growth of a $10,000 Investment in Stock Advisor, Can Pfizer's COVID Vaccine Beat the South African Variant? Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. Pfizerâs vaccine seems to offer good protection against the South African variant of COVID-19, while British data has given AstraZeneca a lift, in ⦠However, there are concerns about how effective the vaccine might be against emerging variants. This means that the Pfizer vaccine does not provide the same level of protection against the South African variant. The Pfizer Covid-19 vaccine looks to offer 100% protection against the South African variant, and is mostly likely highly effective against the variant that originated in ⦠âThe fact that there is real-world data that shows the Pfizer vaccine works very well against the South African variant, it's quite likely that both the Pfizer and Moderna vaccines will be ⦠Orelli: Pfizer did do a study where they showed 100% efficacy against the South African variant. How Big Is Pfizer's Vaccine Opportunity in India? If they do it poorly, even high rates of vaccination are unlikely to stop the virus circulating. No cases of the disease were observed in South Africa during the phase-three trial study among participants who had received their second dose, the companies said in a statement. Market data powered by FactSet and Web Financial Group. But that small study was more suggestive than conclusive, and researchers are still waiting for better data to come in. The South African variant, B.1.351, was found to make up about 1% of all the COVID-19 cases across all the people studied. The mutant South African Covid variant can 'break through' the Pfizer jab 'to some extent', a study has found Credit: EPA It matched age and gender, among other characteristics. There is no doubt about that.”. All this tells us really is that the vaccine is less protective against the South African variant than it is against the regular variant. But I think if I recall correctly, it was like ⦠Pfizer 's Covid vaccine still works against the South African and Brazilian variants of the virus and protection lasts for at least six months, studies suggested today. Orelli: Pfizer did do a study where they showed 100% efficacy against the South African variant. The New England Journal of Medicine last week printed a letter from Qatari-based scientists; about half that country’s cases are from the South African variant, with the Pfizer vaccine being quickly rolled out to quell a new outbreak. Nurse Sioban Cheesman gives Angela Massie her AstraZeneca COVID-19 vaccine in Perth earlier this month.Credit:Getty Images. We’re sorry, this service is currently unavailable. Pfizer, for example, is already evaluating a third booster dose to see how that works. Pfizer/BioNTechâs Covid vaccine is not strong enough to resist the Covid mutation that was first discovered in South Africa. Returns as of 05/19/2021. The company is looking at a modified version of its vaccine that targets the variance specifically, Moderna is testing a modified version of its vaccine that targets the South African variant. But clearly, as we already knew, the vaccines are 100%. However, the study is limited by the fact the researchers did not explicitly test each infected person to see if they had contracted the South African variant. No, not necessarily,” said Professor Russell. This article represents the opinion of the writer, who may disagree with the âofficialâ recommendation position of a Motley Fool premium advisory service. In unvaccinated people, the South African variant was 0.7% infections, so that would be like basically the baseline of the viruses in Israel. Weâre motley! But that's not what we're measuring. Speights: It's not surprising in the least that any of these vaccines would be less effective against the South African variant. I think there's reason for optimism that we're going to have vaccines that are safe and effective against any of these new emerging variants. Please try again later. Liam is The Age and The Sydney Morning Herald's science reporter, Pfizer beats back variants as AstraZeneca receives a timely boost. The Pfizer vaccine appeared to be less effective against the South African variant, researchers said, and has the ability to 'evade' protection. Even if it's 95% or 90% or 80%, I don't think you would have expected to see 1 in 6 necessarily. No one is complaining about the efficacy of Pfizer's (NYSE:PFE) COVID-19 vaccine in providing protection against the currently dominant coronavirus strain in the United States. We have to wait and see, but what happens in the real world is the most important.”. cut the ability of antibodies to stop it binding to and entering human cells, offered no protection against catching it, printed a letter from Qatari-based scientists. Examine is a free weekly newsletter by science reporter Liam Mannix. @themotleyfool #stocks $PFE $BNTX $MRNA. A new British study, uploaded to medRxiv but not yet peer reviewed, found essentially no difference between the protection offered by Pfizer and AstraZeneca’s jabs. They simply assumed that if they did not have the British variant they must have the South African virus. “It’s really good news,” said Associate Professor James Wood, a leading vaccine expert at the University of NSW. Pfizer trial finds vaccine â100% effectiveâ against South African variant. The BioNTech/Pfizer Covid-19 vaccine appears to be significantly less effective against the virus variant that emerged in South Africa, according to a study published on Wednesday. More than 300 cases of the South African variant have been detected in more than 25 U.S. states and jurisdictions, according to federal data. Emerging data from Britain also suggests AstraZeneca’s much-maligned vaccine works just as well as Pfizer’s mRNA jab in the real world, with two doses of either vaccine cutting the risk of contracting COVID-19 by as much as 70 per cent. Then people who had been vaccinated with Pfizer and BioNTech's vaccine, the South African variant, meet up 5.4%, seven times as much as something, eight times as much. Of those nine cases, six were among individuals infected with the South African variant. “A lot of the differences in clinical trial results are likely based on study design, the populations enrolled, the variants circulating. Brian Orelli: This wasn't a placebo-controlled trial, it was more of a surveillance study. His background includes serving in management and consulting for the healthcare technology, health insurance, medical device, and pharmacy benefits management industries. But drugs often work differently in the outside world, compared to carefully controlled clinical trials. MATT HANCOCK has admitted that the Pfizer vaccine needs two doses in order to reach the desired efficacy levels against the South African coronavirus variant. That makes earlier, similar findings in Scotland – where AstraZeneca’s vaccine was somehow more effective than Pfizer’s – appear more plausible (a US study published earlier this month put Pfizer’s real-world effectiveness at 90 per cent, but studied a much smaller number of people). Matt Hancock says he is 'incredibly worried' about the South Africa variant Nurse Sioban Cheesman gives Angela Massie her AstraZeneca COVID-19 vaccine in Perth earlier this month. In cases where the sick person had received a vaccine, the chances of them passing on the virus to someone else in the house dropped by about 50 per cent. We're just assuming they got infected what percentage of the people have the South African variant. Pfizer-BioNTech's COVID-19 vaccine produces a weakened immune response against the contagious variant found in South Africa, which has now also been identified in the US, a new study has suggested. Pfizer and BioNTech said Thursday their coronavirus vaccine's efficacy against the South African variant was very high in the latest phase of ongoing clinical trials. After two doses, the Pfizer vaccine was about 70 per cent effective against the South African variant, and about 97 per cent effective against serious illness and death, they said. In this Motley Fool Live video recorded on April 14, 2021, Motley Fool contributors Keith Speights and Brian Orelli discuss whether or not Pfizer's vaccine will be able to beat the South African variant. Keith Speights: Results from a real-world study conducted in Israel were announced recently and it showed that the South African variant that's caused a lot of concern, the South African variant could evade Pfizer's COVID-19 vaccine. “I’m not a big fan of that study,” said Professor Wood. “Vaccinologists ... all thought probably most of the vaccines would work similarly and have a similar effectiveness. Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer. The South African variant of the deadly coronavirus can âbreak through" the Pfizer-BioNTechâs vaccine to some extent, a study in Israel concluded. "We found a ⦠New study from Tel Aviv University, Clalit Research Institute, shows Pfizer-BioNTech coronavirus vaccine offers significant but reduced protection against South African coronavirus variant. Brian, what do you make of this particular analysis, and could Pfizer's vaccine face some big problems with this coronavirus variant? Pfizer-BioNTech's COVID-19 vaccine appeared to be 100% effective at preventing cases of the South African variant, B.1.351, the two firms announced Thursday. “Is that a surprise? “It does present herd immunity as a much more achievable proposition in Australia, with our vaccine mix – with the caveat we don’t know what we’ll be seeing in six months’ time.”. “Certainly, Pfizer is a great vaccine. How Potential FDA Approval of Pfizer's COVID Vaccine Matters to Investors, Why Pfizer Stock Didn't Soar After Its Fantastic Q1 Results, Why Wall Street Is Worried About Pfizer Despite Its COVID Vaccine Success, Copyright, Trademark and Patent Information. Pfizer and BioNTech have released some extraordinary findings from a Phase 3 trial involving 46,307 participants, between seven days and six months after a second dose was administered.
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