In this study, we explored public databases, including Cancer Genome Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Type 1 collagen is the most abundant type in the body and found in skin, tendon, vascular ligature, organs, and bone. There are differences in phenotypes of mutations in the COL3A1 gene in humans and mutations in mice. COL5A1 collagen, type V, alpha 1 new data last added: 23 December 2015 View new COL5A1 data and updates. Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse. Not tested. Chen HY, Chung YW, Lin WY, Wang JC, Tsai FJ, Tsai CH. 1985b . Procollagen III was converted to mature collagen by controlled proteinase digestion. In foetal tissues also homotrimers of alpha-1 (I) are found, but they are not constituents of normal adult tissues. Disclaimer. Synonyms EDS4A, EDSVASC, PMGEDSV . Alliance of Genome Resources. Description: Quantitativesandwich ELISA kit for measuring Human Collagen, type III, alpha 1 (COL3A1) in samples from serum, plasma, cell culture supernates, tissue homogenates. It is not intended for diagnostic use. Int J Gynaecol Obstet, 103(1):55-58, 22 Aug 2008 Cited by: 34 articles | PMID: 18722615 Recombinant Human collagen-III encoding proalpha (III) and both alpha and beta subunits of the prolyl hydoxylase were coexpressed in the yeastPichia Pastoris. The 1466-amino acid protein is a member of the Fibrillar collagen family. 1985a . Identification of the promoter and first exon of the mouse alpha 1 (III) collagen gene . Dilute with water as needed prior to use. Suitable for use as a control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve . Significant. Buffer System: 0.5M Acetic Acid containing 0.01% Sodium Azide (w/v) as preservative and without stabilizers. Type III collagen is a fibrillar-forming collagen comprising 3 alpha-1 (III) chains and is expressed in early embryos and throughout embryogenesis. 2020 Sep;24(18):10803-10815. doi: 10.1111/jcmm.15705. Haploinsufficiency mutations in COL4A1 interrupt the basement membrane integrity, causing hemorrhagic stroke.1 Recently, mutations causing overproduction of COL4A1 mRNA have been identified in patients with cerebral small vessel disease (CSVD), including in members of families with pontine autosomal dominant . The start of the first exon . In order to investigate whether the regulation and gene network of COL3A1 is the same in healthy populations of mice and humans, we compared the quantitative trait loci (QTL) that regulate . collagen type II alpha 1 chain(COL2A1) collagen type III alpha 1 chain(COL3A1) collagen type IV alpha 1 chain(COL4A1) collagen type IV alpha 2 chain(COL4A2) collagen type IV alpha 3 chain(COL4A3) collagen type IV alpha 4 chain(COL4A4) collagen type IV alpha 5 chain(COL4A5) collagen type IV alpha 6 chain(COL4A6) collagen type V alpha 1 chain(COL5A1) All reagents provided are stored at 2-8°C. Collagen Type III Alpha 1 (COL3A1) is aberrantly expressed in a variety of cancers. In one of our previous studies however, polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) misdiagnosed rs1800255, COL3A1 2209 G>A in 6 % of cases. In adult, type III collagen is a major component of the extracellular matrix in a variety of internal organs and skin (Liu et al., 1997). Collagen Type III, rat. Description: Quantitativesandwich ELISA kit for measuring Human Collagen, type III, alpha 1 (COL3A1) in samples from serum, plasma, cell culture supernates, tissue homogenates. Collagen type III is found in most soft connective tissues, such as skin, lung, and the vascular system, often in association with type I collagen. of the samples to the standard curve. . Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (), each called an alpha 1 chain of type III collagen.Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded by the COL3A1 gene.Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. 1 Human Collagen, Type III, Alpha 1 (COL3A1) ELISA Kit Catalog Number. 84032. Coordinate regulation of the levels of Type III and Type I collagen mRNA in most but not all mouse fibroblasts . Supplier: MyBiosource. Every 10 th amino acid is shown in bold. COL3A1, collagen type III alpha 1 chain Vertebrate Orthologs 2 Vertebrate Orthology Source. collagen, type III, alpha 1 [HGNC] PubMed References. We investigated whether children with inflammatory CD (B1) who later develop strictures . 1. An antibody specific for COL3A1 has been pre-coated onto a microplate. Collagen exists in 16 different types, and most abundant types are type 1, 2 and 3. Product information "COL3A1, Human collagen, type III, alpha 1, Real Time PCR Primer Set". Collagens consist of a family of highly specialized . 1 Some study indicated that it promoted tumour genesis by regulating the angiogenesis process, and it was defined as an oncogene. Each molecule of type III procollagen is made up of three copies of this chain. The position of introns is indicated by a vertical line, splitting the two exons. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Collagen Type III Alpha 1 (COL3a1). Cloning and Expression. Collagen type IV alpha 1 (COL4A1) is a major basement membrane component. Type I Collagen usually exists as a heterotrimer formed by alpha 1 (I) and alpha 2 (I) chains and is found in bone, cornea, skin and tendon. COL3A1 (collagen type III alpha 1 chain) Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) Non-annotated gene. This ELISA kit for research use only, not for therapeutic or diagnostic applications! Collagen type III alpha 1 chain human protein, 0.5 mg. >98% Chromatographically and immunologically pure. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. Nevertheless, the role of COL3A1 in pan- cancer stays unidentified. No Body Weight Data No Embryo Imaging Data No Viability Data IMPC Phenotype Summary. COL3A1 is defined as Collagen, Type III, Alpha1 very rarely. Collagen, type III, alpha 1 is a reported alias name for the human gene COL3A1, or 'collagen type III alpha 1 chain'. It is a trimer of alpha 1(III) chains that are linked by interchain disulfide bonds. Defective collagen type III is a cause of Ehlers-Danlos syndrome types III and IV and arterial aneurisms (1). collagen type IV alpha-3 gene collagen type IV α-3 gene a mutation of this gene is responsible for some cases of Alport syndrome; located at 2q36-37; gene encodes protein components of the glomerular basement membrane in the kidney and of the basilar membrane, spiral ligament, and stria vascularis of the cochlea. human cancers. So, for example, if a gene is known to encode a subunit of a complex, it is named to reflect this, for example, origin recognition complex, subunit 3 (ORC3), and likewise if it encodes a structural protein, for example, collagen type III, alpha 1 (COL3A1).If a gene encodes an enzyme, the gene is named for the . And R version 3.6.1 was utilized for analysis in silico (Institute for Statistics and Mathematics, Vienna, Austria; www.r-proje This ELISA kit is for research use only, not for therapeutic or diagnostic applications. Collagen type III occurs in most soft connective tissues along with type I collagen. See the supplier page to learn important antibody details . The extracellular matrix components, collagen type III alpha 1 chain (COL3A1) and cartilage oligomeric matrix protein (COMP), could contribute to intestinal fibrosis. DSE The concentration of Collagen Type III Alpha 1 (COL3a1) in the samples is then determined by comparing the O.D. References Haploinsufficiency for one COL3A1 allele of type III procollagen results in a phenotype similar to the vascular form of Ehlers-Danlos syndrome, Ehlers-Danlos syndrome type IV. This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. Collagen III is synthesized as a homotrimer consisting three identical . The ELISA kits listed below target COL3A1, the symbol for the human gene, collagen type III alpha 1 chain, and a member of the Fibrillar collagen family.
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